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Ingrediente ativo: Tolterodine
Marca (s): Detrol

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What is Tolterodine

Tolterodine is a aggressive cholinergic receptor antagonist with selectivity for the bladder. It will increase bladder capability, delays the primary urge to urinate and reduces micturition frequency in hyperactive bladder.

Tolterodine Drug Recommendation

For urgency incontinence, bladder retraining is the primary alternative. If insufficiently efficient, assist therapy with a controlled-release oral anticholinergic and/or once-daily dosage (darifenacin, fesoterodine, tolterodine, solifenacin). Commonly focus on whether or not the optimistic impact achieved outweighs the uncomfortable side effects:

  • boca seca
  • constipação
  • imaginative
  • prescient issues
  • cognitive problems


  • Symptomatic therapy of elevated urgency
  • frequent micturition and/or urgency incontinence
  • overactive bladder syndrome

O que você deve discutir com seu médico antes de usar este medicamento

  1. Estar grávida
    • Teratogenesis: In people, inadequate knowledge. Indications of harmfulness in animals.
  2. Lactação
    • Transição no leite materno: Desconhecido.
  3.  Contra-indicações
      • urinary retention;
      • extreme ulcerative colitis, poisonous megacolon;
      • myasthenia gravis;
      • inadequately regulated narrow-angle glaucoma.

Tolterodine Drug Interactions

Notably in case of ‘poor metabolizers’ watch out when combining with robust CYP3A4 inhibitors:

  • eritromicina
  • claritromicina
  • cetoconazol
  • itraconazol
  • miconazole
  • Inibidores de protease de HIV

Additionally watch out when combining with medicines that extend the QT interval

  • quinidina
  • disopiramida
  • sotalol
  • antidepressivos tricíclicos
  • alguns antipsicóticos
  • antibióticos macrolídeos
  • fluoroquinolonas
  • alguns antimicóticos

Anticholinergic results could also be added when used along with different brokers which have a parasympathetic impact. Tolterodine reduces the impact of brokers that promote gastrointestinal motility. The impact of tolterodine is decreased by parasympathicomimetics.

Tolterodine Dosage

Regardless of variations in pharmacokinetics between ‘ultra-rapid’ and ‘poor metabolisers’ (CYP2D6), the scientific response to the identical dose of tolterodine is comparable in each varieties of sufferers.

  • Elevated urgency, frequent micturition and/or urgency incontinence
    • Adultos
      • Really helpful dose: 2 mg 2×/day or 4 mg managed launch capsule (mga) 1×/day. In case of troublesome uncomfortable side effects: 1 mg 2×/day or 2 mg capsule mga 1×/day. After 2-3 months, consider the necessity for additional therapy.
      • In case of impaired hepatic or extreme renal operate (≤ 30 ml/min): 1 mg 2×/day or 2 mg capsule mga 1×/day.
    • Administration: swallow the capsule complete.

Sinais de overdose

  • Relying on severity:
    • lodging problems
    • problemas de micção
    • taquicardia
    • insuficiência respiratória
    • central anticholinergic results
      • extreme pleasure
      • alucinações
    • convulsões

Remedy: If nonetheless helpful, gastric lavage and administration of activated charcoal. Deal with tachycardia with a β-blocker, urinary retention with catheterisation, pronounced agitation or convulsion with a benzodiazepine and extreme central anticholinergic results with physostigmine.

Tolterodine Precautions

Use warning with: important obstruction of the urinary or gastrointestinal tract; additionally with:

  • autonomic neuropathy
  • hiatus hernia
  • renal or hepatic insufficiency

Additionally watch out with threat elements for QT prolongation equivalent to:

  • bradicardia
  • hipocalemia
  • hipocalcemia
  • hipomagnesemia
  • comedication with medicine that extend QT interval
  • prolongamento QT congênito ou adquirido
  • current cardiac ailments equivalent to:
    • arrhythmia
    • myocardial ischaemia
    • insuficiência cardíaca coronária

The efficacy of tolterodine in youngsters has not been demonstrated. This drugs might have an effect on the flexibility to drive and use machines. 

Detrol Side Effects

  • boca seca
  • Dor de cabeça
  • palpitações
  • Dizziness, paraesthesia, drowsiness, fatigue
  • Dry pores and skin
  • Dry eyes, imaginative and prescient impairment, lodging issues
  • Dyspepsia, vomiting, stomach ache, constipation, diarrhoea, flatulence
  • Dysuria, urinary retention
  • Sinusitis, bronchitis
  • Peripheral oedema
  • Aquisição de peso
  • Dor no peito
  • taquicardia
  • arrhythmia
  • insuficiência cardíaca coronária
  • Nervousness, reminiscence loss, improve in dementia
  • Gastro-oesophageal reflux
  • Hypersensitivity

The next have additionally been reported: anaphylactic reactions together with angioedema. Flushing (extreme). Confusion, hallucinations, disorientation. When utilizing the controlled-release capsule, some uncomfortable side effects happen at a decrease frequency.

aviso Legal

Information concerning psychotic disorders, included within the review of Tolterodine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


⚠ Isenção de responsabilidade

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Neste site, não vendemos medicamentos e encaminhamos os visitantes para provedores de Internet confiáveis. Desta forma, poupamos a si e ao melhor preço às pessoas muitos problemas e poderá obter de forma fácil e legal este poderoso medicamento.

Perguntas frequentes

  • What is Tolterodine Detrol?

    Detrol contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.

  • O que fazer se você falhar uma dose?

    If you miss a dose of Tolterodine, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Zanaflex?

    Se ocorrer uma overdose, chame seu médico ou ligue para o hospital mais próximo. Você pode ter cuidados médicos urgentes. Você também pode entrar em contato com a gerência de veneno do hospital local.

  • How to store Tolterodine?

    Armazene em temperatura ambiente de 15-30 C (59-86 F) longe de umidade e calor.

  • What Should I Avoid While Taking Tolterodine?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Detrol. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Tolterodine Detrol?

    Os efeitos colaterais mais comuns incluem dor no peito, frequência cardíaca rápida ou irregular, confusão, dor ou dificuldade para urinar, alucinações, urinar menos do que o normal ou nem urinar.

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Última atualização em 19 de novembro de 2021 por Toni El Clikos

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