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Brand Names and Dosages

  • Cymbalta® Capsules (delayed launch): 20 mg, 30 mg, 60 mg
  • Drizalma Sprinkle™ Capsules (delayed launch sprinkle): 20 mg, 30 mg, 40 mg, 60mg
  • Duloxetine Capsules (delayed launch): 20 mg, 30 mg, 40 mg, 60 mg

Generic identify: Duloxetine (doo LOX e teen)

What Is Duloxetine And where it is used for?

Duloxetine is an antidepressant remedy that works within the mind. It is authorised for the therapy of main depressive dysfunction (MDD), generalized anxiousness dysfunction (GAD), diabetic peripheral neuropathic ache (DPNP), fibromyalgia, and power musculoskeletal ache.

Symptoms of despair embody:

  • Depressed temper – feeling unhappy, empty, or tearful
  • Feeling nugatory, responsible, hopeless, and helpless
  • Loss of curiosity or pleasure in your normal actions
  • Sleep and eat kind of than normal (for most individuals it’s much less)
  • Low vitality, hassle concentrating, or ideas of demise (suicidal considering)
  • Psychomotor agitation (‘nervous energy’)
  • Psychomotor retardation (feeling like you’re shifting and considering in sluggish movement)
  • Suicidal ideas or behaviors

Generalized Anxiety Disorder (GAD) happens when an individual experiences extreme anxiousness or fear for a minimum of six months. Other signs embody:

  • Restlessness
  • Fatigue (low vitality, feeling drained on a regular basis)
  • Difficulty concentrating
  • Irritability
  • Muscle rigidity
  • Sleep disturbance (issue falling asleep or waking up in the midst of the night time)

What you need to know before using Duloxetine?

Do not cease taking duloxetine, even while you really feel higher. With enter from you, your well being care supplier will assess how lengthy you’ll need to take the medication.

  • Missing doses of duloxetine might improve your danger for relapse in your signs.
  • Stopping duloxetine abruptly might end in a number of of the next withdrawal signs: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the pores and skin).
  • Depression can also be part of bipolar sickness. People with bipolar dysfunction who take antidepressants could also be in danger for “switching” from despair into mania. Symptoms of mania embody “high” or irritable temper, very excessive shallowness, decreased want for sleep, stress to maintain speaking, racing ideas, being simply distracted, continuously concerned in actions with a big danger for dangerous penalties (for instance, extreme shopping for sprees).

Medical consideration must be sought if serotonin syndrome is suspected. Please seek advice from critical negative effects for indicators/signs.

Are There Specific Concerns About Duloxetine And Pregnancy?

If you’re planning on changing into pregnant, notify your well being care supplier to greatest handle your medicines. People dwelling with MDD who want to turn into pregnant face vital selections. Untreated MDD has dangers to the fetus, in addition to the mom. It is vital to debate the dangers and advantages of therapy together with your physician and caregivers. For girls who take antidepressant medicines throughout weeks 13 by the tip of their being pregnant (second and third trimesters), there’s a danger that the child might be born earlier than it’s absolutely developed (earlier than 37 weeks).

Caution is suggested with breastfeeding since duloxetine does cross into breast milk.

What Should I Discuss With My Health Care Provider Before Taking Duloxetine?

  • Symptoms of your situation that hassle you essentially the most
  • If you could have ideas of suicide or harming your self
  • Medications you could have taken prior to now in your situation, whether or not they have been efficient or brought about any hostile results
  • If you expertise negative effects out of your medicines, focus on them together with your supplier. Some negative effects might cross with time, however others might require adjustments to the remedy.
  • Any different psychiatric or medical issues you could have, together with a historical past of bipolar dysfunction, kidney or liver illness
  • All different medicines you’re presently taking (together with over-the-counter merchandise, natural and dietary dietary supplements) and any remedy allergy symptoms you could have
  • Other non-medication therapy you’re receiving, akin to speak remedy or substance abuse therapy. Your supplier can clarify how these totally different remedies work with the remedy.
  • If you’re pregnant, plan to turn into pregnant, or are breastfeeding
  • If you drink alcohol or use medication

How Should I Take Duloxetine?

  1. Duloxetine is often taken 1 or 2 occasions per day with or with out meals.
  2. Typically, sufferers start at a low dose of medication and the dose is elevated slowly over a number of weeks.
  3. The dose often ranges from 20 mg to 120 mg. Only your well being care supplier can decide the proper dose for you.
  4. The capsule must be swallowed complete. It shouldn’t be chewed, crushed, or damaged.
  5. The duloxetine delayed launch capsule (Cymbalta® or generic duloxetine) must be swallowed complete. It shouldn’t be chewed, crushed, or damaged. Drizalma Sprinkle™ delayed launch capsules could also be opened and sprinkled on applesauce, if wanted.

    Consider utilizing a calendar, pillbox, alarm clock, or mobile phone alert that can assist you keep in mind to take your remedy. You can also ask a member of the family or a good friend to remind you or verify in with you to make sure you’re taking your remedy.

What Happens If I Miss A Dose Of Duloxetine?

If you miss a dose of duloxetine take it as quickly as you keep in mind, until it’s nearer to the time of your subsequent dose. Discuss this together with your well being care supplier. Do not double your subsequent dose or take greater than what’s prescribed.

What Should I Avoid While Taking Duloxetine?

Avoid ingesting alcohol or utilizing unlawful medication if you are taking antidepressant medicines. They might lower the advantages (e.g., worsen your situation) and improve hostile results (e.g., sedation) of the remedy. Alcohol will increase the chance of liver issues with duloxetine.

What Happens If I Overdose With Duloxetine?

If an overdose happens, name your physician or 911. You might have pressing medical care. You can also contact the poison management heart at your nearest hospital

A selected therapy to reverse the results of duloxetine doesn’t exist.

What Are Possible Side Effects Of Duloxetine?

Common negative effects

Headache, nausea, diarrhea, dry mouth, decreased urge for food, elevated sweating, feeling nervous, stressed, fatigued, sleepy or having hassle sleeping (insomnia). These will usually enhance over the primary week or two as you proceed to take the remedy.

Sexual negative effects, akin to issues with orgasm or ejaculatory delay, and blood stress will increase usually don’t enhance over time.

Rare/critical negative effects

There have been uncommon stories of liver failure (typically deadly) with duloxetine. This danger is elevated in these with substantial alcohol use or power liver illness.

Orthostatic hypotension, or a drop in blood stress when standing or getting up from sleeping, has been reported in sufferers taking duloxetine. The danger could also be larger in sufferers additionally taking medicines for hypertension.

Increased coronary heart fee, irregular menstrual cycle, elevated frequency of urination or issue urinating, elevated liver enzymes, tooth grinding, low sodium (signs of low sodium ranges might embody headache, weak spot, issue concentrating and remembering), angle closure glaucoma (signs of angle closure glaucoma might embody eye ache, adjustments in imaginative and prescient, swelling or redness in or round eye), serotonin syndrome (signs might embody shivering, diarrhea, confusion, extreme muscle tightness, fever, seizures, and demise), hypertensive disaster (severely elevated blood stress), myocardial infarction (coronary heart assault), Stevens-Johnson Syndrome (rash), pancreatitis

SNRI antidepressants, together with duloxetine, might improve the chance of bleeding occasions. Combined use of aspirin, nonsteroidal anti-inflammatory medication (e.g., ibuprofen, naproxen), warfarin, and different anti-coagulants might improve this danger. This might embody gums that bleed extra simply, nostril bleed, or gastrointestinal bleeding. Some instances have been life threatening.

Are There Any Risks For Taking Duloxetine For Long Periods Of Time?

To date, there are not any identified issues related to long run use of duloxetine. It is a secure and efficient remedy when used as directed.

What Other Medications May Interact With Duloxetine?

Duloxetine shouldn’t be taken with or inside 2 weeks of taking monoamine oxidase inhibitors (MAOIs). These embody phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azalect®) and selegiline (Emsam®).

Although uncommon, there’s an elevated danger of serotonin syndrome when duloxetine is used with different medicines that improve serotonin, akin to different antidepressants, migraine medicines known as “triptans” (e.g., Imitrex®), some ache medicines (e.g., tramadol (Ultram®), the antibiotic linezolid (Zyvox®), and amphetamines.

The following medicines might improve the degrees and results of duloxetine: cimetidine (Tagamet®), ciprofloxacin (Cipro®), fluoxetine (Prozac®), fluvoxamine (Luvox®), paroxetine (Paxil®)

Duloxetine might improve the results of different medicines that may trigger bleeding (e.g., ibuprofen (Advil®, Motrin®), warfarin (Coumadin®) and aspirin).

How Long Does It Take For Duloxetine To Work?

Sleep, vitality, or urge for food might present some enchancment throughout the first 1-2 weeks. Improvement in these bodily signs might be an vital early sign that the remedy is working. Depressed temper and lack of curiosity in actions might have as much as 6-8 weeks to completely enhance.

Summary Of  Warnings

Depression and sure different psychiatric problems are themselves related to will increase within the danger of suicide. Patients with main depressive dysfunction (MDD), each grownup and pediatric, might expertise worsening of their despair and/or the emergence of suicidal ideation and habits (suicidality) or uncommon adjustments in habits, whether or not or not they’re taking antidepressant medicines. This danger might persist till important remission happens.

In short-term research, antidepressants elevated the chance of suicidality in kids, adolescents, and younger adults when in comparison with placebo. Short-term research didn’t present a rise within the danger of suicidality with antidepressants in comparison with placebo in adults past age 24. Adults age 65 and older taking antidepressants have a decreased danger of suicidality. Patients, their households, and caregivers must be alert to the emergence of hysteria, restlessness, irritability, aggressiveness and insomnia. If these signs emerge, they need to be reported to the affected person’s prescriber or well being care skilled. All sufferers being handled with antidepressants for any indication ought to look ahead to and notify their well being care supplier for worsening signs, suicidality and strange adjustments in habits, particularly throughout the first few months of therapy.

Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.

Frequently asked questions

  • What is Duloxetine?

    Antidepressant duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Cymbalta duloxetine changes brain chemicals that may be out of balance in depressed persons. Duloxetine may help you feel better, sleep better, eat more, have more energy, and be less worried.

  • What to do if you miss a dose?

    If you forget to take a Duloxetine dose, take it as soon as you remember until your next dose. This is something you should discuss with your healthcare provider.

  • What if u take too much Duloxetine?

    If an overdose happens call the emerggency center. You might have pressing medical care. You might also a Poison Control Center immediately.

  • How to store Duloxetine?

    Store away from light and moisture at room temperature.

  • What Should I Avoid While Taking Duloxetine?

    If you're on antidepressant medication, avoid drinking alcohol or doing illegal drugs. If you stand up too quickly from a sitting or laying position, you may become dizzy. Avoid driving or engaging in dangerous activities until you have a better understanding of how duloxetine will impact you.

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Last Updated on September 15, 2021 by Toni El Clikos

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