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Brand names:

  • Wellbutrin SR® Tablets: 100 mg, 150 mg, 200 mg
  • Wellbutrin XL® Tablets: 150 mg, 300 mg
  • Zyban® Tablets: 150 mg
  • Forfivo XL® Tablets: 450 mg
  • Aplenzin® Tablets: 174 mg, 348 mg, 522 mg
  • Bupropion hydrochloride
  • Immediate launch tablets: 75mg, 100 mg
  • Sustained launch tablets: 100 mg, 150 mg, 200 mg
  • Extended launch tablets: 150 mg, 300 mg
  • Extended launch tablets: 174 mg, 348 mg, 522 mg

Generic identify: bupropion (byoo PRO pee on)

All warnings are on the end of this page. Please evaluation earlier than taking this treatment.

What Is Bupropion And What Does It Treat?

Bupropion is an antidepressant treatment that works within the mind. It is authorized for the therapy of main depressive dysfunction (MDD), seasonal affective dysfunction (SAD), and to assist individuals stop smoking (smoking cessation).

Symptoms of melancholy embrace:

  • Depressed temper – feeling unhappy, empty, or tearful
  • Feeling nugatory, responsible, hopeless, and helpless
  • Loss of curiosity or pleasure in your normal actions
  • Sleep and eat kind of than normal (for most individuals it’s much less)
  • Low power, hassle concentrating, or ideas of loss of life (suicidal considering)
  • Psychomotor agitation (‘nervous energy’)
  • Psychomotor retardation (feeling like you might be shifting and considering in gradual movement)
  • Suicidal ideas or behaviors

SAD is a sort of melancholy that happens primarily throughout the autumn-winter season. Although the frequent time period SAD is now known as Major Depression with Seasonal Pattern, this truth sheet will proceed to make use of SAD as it’s extra generally identified.

Bupropion can also be useful when prescribed “off-label” for bipolar dysfunction, consideration deficit hyperactivity dysfunction (ADHD, and sexual dysfunction as a consequence of SSRI antidepressants. “Off-label” implies that it hasn’t been authorized by the Food and Drug Administration for this situation. Your psychological well being supplier ought to justify his or her considering in recommending an “off-label” therapy. They needs to be clear concerning the limits of the analysis round that treatment and if there are another choices.

What Is The Most Important Information I Should Know About Bupropion?

After beginning bupropion, signs regularly lower over a interval of weeks. In MDD and SAD, sleep and different bodily signs might enhance earlier than there may be noticeable enchancment in temper or curiosity in actions. Once signs are underneath management, MDD normally requires long-term therapy to assist stop the return of depressive signs. If you might be utilizing bupropion for SAD or smoking cessation, the size of your therapy could also be shorter. With enter from you, your well being care supplier will assess how lengthy you have to to take the medication.

Do not cease taking bupropion or change your dose with out speaking together with your well being care supplier first.

Depression can also be part of bipolar sickness. People with bipolar dysfunction who take antidepressants could also be in danger for “switching” from melancholy into mania. Symptoms of mania embrace “high” or irritable temper, very excessive shallowness, decreased want for sleep, strain to maintain speaking, racing ideas, being simply distracted, regularly concerned in actions with a big threat for unhealthy penalties (for instance, extreme shopping for sprees).

Are There Specific Concerns About Bupropion And Pregnancy?

If you might be planning on turning into pregnant, notify your well being care supplier to greatest handle your drugs. People residing with MDD who want to grow to be pregnant face vital choices, every with dangers and advantages as they relate to how the sickness, drugs, and dangers to the fetus might work together. Untreated MDD has dangers to the fetus, in addition to the mom. It is vital to debate the dangers and advantages of therapy together with your physician and caregivers. 

Bupropion has additionally been evaluated for smoking cessation throughout being pregnant and is advisable solely after different therapies have failed.

Caution is suggested with breastfeeding since bupropion does cross into breast milk.

What Should I Discuss With My Health Care Provider Before Taking Bupropion?

  • Symptoms of your situation that trouble you most
  • If you could have ideas of suicide or harming your self
  • Medications you could have taken up to now in your situation, whether or not they had been efficient or brought about any opposed results
  • If you expertise unintended effects out of your drugs, focus on them together with your supplier. Some unintended effects might cross with time, however others might require an adjustment within the treatment. 
  • Any different psychiatric or medical issues you could have, together with a historical past of bipolar dysfunction
  • All different drugs you might be at present taking and any treatment allergic reactions you could have. This will assist your prescriber assess for potential drug interactions. 
  • Other non-medication therapy you might be receiving (equivalent to psychotherapy (i.e., speak remedy) or substance abuse therapy). Your supplier can clarify how these completely different therapies work with the treatment. 
  • If you might be pregnant, plan to grow to be pregnant, or are breastfeeding
  • If you drink alcohol or use medication

How Should I Take Bupropion?

Bupropion hydrochloride is obtainable in 3 completely different types: fast launch (IR), sustained launch (SR), and prolonged launch (XL).

  1. Bupropion IR is normally taken 2 or 3 instances per day with 4-6 hours between doses. The dose normally ranges from 100 mg twice every day to 150 mg thrice every day, with the final dose taken mid-afternoon.
  2. Bupropion SR is normally taken twice every day within the morning and mid-afternoon. The dose normally ranges from 100 mg twice every day as much as 200 mg twice every day.
  3. Bupropion XL is normally taken as soon as every day within the morning. The dose ranges from 150 mg to 450 mg.
  4. Bupropion hydrobromide (Aplenzin®) is normally taken as soon as every day within the morning. The dose ranges from 174 mg to 522 mg.
  5. While there are dose ranges for every kind, your well being care supplier will decide the shape and dose that’s best for you primarily based in your response.
  6. The dose for SAD is bupropion XL 150 mg as soon as every day within the morning. The dose could also be elevated to 300 mg as soon as every day.
  7. The dose for smoking cessation is bupropion SR 150 mg as soon as every day for 3 days after which twice every day for 7 to 12 weeks.

You mustn’t take a couple of product that accommodates bupropion, together with the merchandise which are used to stop smoking. Do not take greater than your prescribed dose since larger doses might improve your threat of getting a seizure. Since rapidly rising the dose of bupropion may cause seizures in some individuals, your physician will slowly improve your dose.

You can take bupropion on an empty abdomen or with meals. The SR and XL types needs to be swallowed complete, not chewed, crushed, or damaged.
In order that the treatment can work accurately in your physique and to scale back the chance of great unintended effects. The pill shell from the SR and XL types might seem in your feces.

Consider utilizing a calendar, pillbox, alarm clock, or cellular phone alert that will help you bear in mind to take your treatment. You can also ask a member of the family or buddy to remind you or test in with you to make certain you’re taking your treatment.

What Happens If I Miss A Dose Of Bupropion?

For bupropion IR or SR, if you happen to miss a dose, take it as quickly as you bear in mind. Take the remaining doses for the day at evenly spaced instances at the least 4 hours aside. DO NOT take 2 doses directly. You mustn’t take greater than your prescribed dose and doing so might improve your threat of getting a seizure.

For bupropion XL, don’t take an additional pill to make up for the dose you forgot. Wait and take your subsequent dose at your common time the subsequent day.

What Should I Avoid While Taking Bupropion?

Avoid consuming alcohol or utilizing unlawful medication if you are taking bupropion as a result of the helpful results of the treatment could also be decreased and the chance of seizures could also be elevated. If you might be depending on medication or alcohol and wish to cease, seek the advice of your healthcare supplier for assist. Abruptly stopping these substances can lead to a seizure, particularly when taking bupropion.

What Happens If I Overdose With Bupropion?

If an overdose happens, name your physician or 911. You might have pressing medical care. You can also contact the poison management heart at your nearest hospital.

What Are The Possible Side Effects Of Bupropion?

Common unintended effects:

  • Headache
  • Weight reduction
  • Dry mouth
  • Hassle sleeping (insomnia)
  • Nausea
  • Dizziness
  • Constipation
  • Quick heartbeat
  • Sore throat

These will typically enhance over the primary week or two as you proceed to take the treatment.

Rare/severe unintended effects

Less than 10% of sufferers will expertise pores and skin rash, sweating, ringing within the ears, shakiness, abdomen ache, muscle ache, thought disturbances, anxiousness or angle closure glaucoma (signs of angle closure glaucoma might embrace eye ache, adjustments in imaginative and prescient, swelling or redness in or round eye).

Unlike many antidepressants, bupropion doesn’t generally trigger sexual unintended effects and could also be chosen as a substitute therapy when antidepressant-induced sexual unintended effects are problematic. Sexual unintended effects embrace such issues as problem reaching orgasm or ejaculatory delay.

In common the chance of seizures as a consequence of bupropion is low. The threat of getting a seizure will increase with larger than advisable doses of bupropion, a historical past of seizures or head harm, tumor within the mind, extreme liver illness, an consuming dysfunction, alcohol or drug dependence, or taking different medication that may additionally improve your threat of getting a seizure.

There is a low threat of cardiovascular opposed occasions related to stimulating brokers, together with bupropion. This threat will increase you probably have coronary heart illness, hypertension, earlier coronary heart assault, or irregular heartbeat, or when used with transdermal nicotine alternative merchandise. In these instances, a radical cardiovascular analysis is advisable earlier than beginning this drugs.

Are There Any Risks For Taking Bupropion For Long Periods Of Time?

To date, there are not any identified issues related to long run use of bupropion. It is a protected and efficient treatment when used as directed.

What Other Medications May Interact With Bupropion?

Bupropion shouldn’t be taken with or inside two weeks of taking monoamine oxidase inhibitors (MAOIs). These embrace phenelzine (Nardil®), tranycypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Emsam®).

There are a number of merchandise with the energetic ingredient bupropion. Do not take a couple of product that accommodates bupropion since this may increasingly improve your threat of getting a seizure.

Certain drugs might improve your threat of getting a seizure when mixed with bupropion. These embrace different antidepressants, antipsychotics, theophylline, isoniazid, tramadol, stimulants, steroids, hypoglycemic brokers (together with insulin), sure antibiotics (e.g., Cipro®), and abrupt discontinuation of benzodiazepines (e.g., Ativan®).

Notify your physician and pharmacist if you’re taking any of the next drugs: phenytoin (Dilantin®), carbamazepine (Tegretol®, Equetro®), phenobarbital, cimetidine (Tagamet®), ritonavir (Norvir®), lopinavir (Kaletra™), nelfinavir (Viracept®), or efavirenz (Sustiva®). These drugs can change the best way your physique reacts to bupropion.

Notify your physician and pharmacist if you’re taking any of the next drugs: atomoxetine (Stratterra®), codeine, tamoxifen, tetrabenazine, thioridazine (Mellaril®), tramadol (Ultram®), or a tricyclic antidepressant. Bupropion can change the best way your physique reacts to those drugs.

How Long Does It Take For Bupropion To Work?

Sleep, power, or urge for food might present some enchancment throughout the first 1-2 weeks. Improvement in these bodily signs could be an vital early sign that the treatment is working. Depressed temper and lack of curiosity in actiities might have as much as 6-8 weeks to totally enhance. 

Summary Warnings

Suicidal ideas or actions in youngsters and adults

Depression and sure different psychiatric problems are themselves related to will increase within the threat of suicide. Patients with main depressive dysfunction (MDD), each grownup and pediatric, might expertise worsening of their melancholy and/or the emergence of suicidal ideation and conduct (suicidality) or uncommon adjustments in conduct, whether or not or not they’re taking antidepressant drugs. This threat might persist till vital remission happens.

In short-term research, antidepressants elevated the chance of suicidality in youngsters, adolescents and younger adults when in comparison with placebo. Short-term research didn’t present a rise within the threat of suicidality with antidepressants in comparison with placebo in adults past age 24. Adults ages 65 and older taking antidepressants have a decreased threat of suicidality. Patients, their households and caregivers needs to be alert to the emergence of tension, restlessness, irritability, aggressiveness and insomnia. If these signs emerge, they need to be reported to the affected person’s prescriber or healthcare skilled. All sufferers being handled with antidepressants for any indication ought to look ahead to and notify their healthcare supplier for worsening signs, suicidality and weird adjustments in conduct, particularly throughout the first few months of therapy.

Disclaimer of liability

Pfizer is not affiliated with this site. The brand name and logos and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market or ship medicines ourselves and refer you to reputable web stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price to people many problems and you can easily and legally obtain this powerful medicine.


Frequently asked questions

  • What is Bupropion?

    Bupropion is an antidepressant treatment that works within the mind. It is authorized for the therapy of main depressive dysfunction (MDD), seasonal affective dysfunction (SAD), and to assist individuals stop smoking (smoking cessation).

  • What to do if you miss a dose?

    For bupropion IR or SR, if you happen to miss a dose, take it as quickly as you bear in mind. Take the remaining doses for the day at evenly spaced instances at the least 4 hours aside. DO NOT take 2 doses directly.

  • What if u take too much Bupropion?

    If an overdose happens name your physician or 911. You might have pressing medical care. You might also contact the poison management heart at your nearest hospital

  • How to store Bupropion?

    Store this drug at room temperature. Keep it between 20° to 25°C (68° to 77°F).

  • What Should I Avoid While Taking Bupropion?

    Avoid consuming alcohol or utilizing unlawful medication if you are taking bupropion as a result of the helpful results of the treatment could also be decreased and the chance of seizures could also be elevated.

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Last Updated on September 14, 2021 by Toni El Clikos

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