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It is often a difficult choice whether or not to take antidepressants. When are antidepressants an option if you suffer from depression anxiety or compulsion, and are there alternatives? How do you choose the right antidepressant? And what do you need to know about starting, changing, and stopping antidepressants? If you have decided to take an antidepressant, a logical question is: what is the best antidepressant?

Antidepressant guide 2021

There are more than 20 different antidepressants available in the and there are different types of antidepressants. Each antidepressant has its own profile that says something about how quickly the drug gets into the brain and ultimately behaves there. If you want to take a look at all the different options you might want to check this store that sells antidepressants without prescription.

How do drugs for depression work?

Medications for depression affect the balance between certain substances in the brain. This usually reduces the symptoms of depression, especially severe depression. You become less gloomy and you regain more pleasure and interest in the things around you. You usually don’t notice that they start working for 3 or 4 weeks. When treating depression, psychotherapy and medications work equally well. In the long run, psychotherapy works better. Discuss with your doctor if you use herbs or self-care products such as NSAIDspassiflora,valerian, St. John’s wort(hypericum). These can affect the medications you are taking and often do not go well with them.

Which antidepressants to choose? What is the best option for me?

It would be ideal to be able to predict which antidepressants work and which do not, based on this information. Unfortunately, we cannot do that at this time. Antidepressants with the same properties work very well for one person but not at all for another. And which antidepressants work best also differs per person. Unfortunately, you can’t know that in advance. Therefore, it is difficult to say in advance what the right antidepressant is. The guidelines list sequences in which antidepressants can be given when a particular drug is not effective.

  • For depression, anxiety, and compulsion, the serotonergic antidepressants (SSRI’s) such as sertraline and (es)citalopram often come out on top, with (relatively) the greatest efficacy­heath and the fewest side effects (see also here). Some antidepressants have more sexual side effects (such as paroxetine), or are more difficult to taper off (such as paroxetine and venlafaxine).Tricyclic antidepressants (TCAs) generally cause (slightly) more side effects, and are therefore not usually used as a first choice.
  • Still, it is not mo­equal to say in advance which antidepressant is best for someone now. Even these ‘best’ antidepressants do not guarantee success. It therefore unfortunately often remains an individual search for a properly working antidepressant with the fewest possible side effects.

Beginning with antidepressant use, what to look out for?

The choice to start taking an antidepressant can only be made after extensive and careful explanation by the treating physician. There should be good information about the pros and cons of the available (combinations of) treatment, and not only about antidepressants. Based on all the information, you can make a decision about the role of antidepressants as part of the treatment together with the treating physician. Important to know before you start taking an antidepressant:

  1. Antidepressants usually work after about four to six weeks, but sometimes earlier. In some anxiety disorders, antidepressants do not work until later, after 6-12 weeks. In the case of obsessive-compulsive disorder, sometimes after 12 weeks. You may experience side effects from day one. The effects on mood, anxiety and compulsion unfortunately come a lot later than any side effects.The dosage is usually built up slowly until the right dose is reached. See also: what dosage should I use?
  2. Sometimes you will suffer from side effects. Often (but not always) side effects pass after a few days to weeks.
  3. Try to have a fixed structure in your day, walk outside (or even exercise) and eat healthy and go to bed at a fixed time. Often, of course, this is incredibly difficult, but there is evidence that antidepressants work better when you get moving and have a set structure to your day. Every little bit can help. And if you have anxiety or obsessive-compulsive symptoms, try to avoid as few situations as possible.

How long should you take antidepressants?

It’s important to be critical about how long you take antidepressants. First, many people use them without them actually working – and you don’t want that. Second, it appears that long-term use can lead to a chemical increase in depression susceptibility in some people. Third, it appears that the longer you use, the more difficult it can be to stop again because of the occurrence of annoying withdrawal symptoms when you buy klonopin, buy bromazepam, buy prozac, buy risperdal, buy seroquel or buy clonazepam.

The use of antidepressants is very personal

It is not certain in advance exactly how long you should take antidepressants. This depends on a number of factors, such as whether you have already experienced depression in the past, how long you have had your symptoms and whether there are any stressful environmental factors that persist.

In general, you are advised to keep using the medication for at least six to nine months after you have recovered. This is to prevent complaints from returning. In some cases, people take antidepressants for years. In that case, it is used to prevent a new depression and it mainly has a preventive effect. But it is important to always critically examine whether they are still needed.

Can you switch between different antidepressants in the meantime?

An antidepressant does not work for everyone. In about 50-60% of patients, treatment with an antidepressant is successful (compared to 30-40% with a placebo pill). If there is no improvement after about four weeks (in social phobia and compulsion 12 weeks) while the dosage is sufficiently high, it is really worth considering switching to another antidepressant. If there is some improvement, then it makes sense to continue with the same drug until at least the sixth week (depression), 12e week (social phobia and compulsion) and possibly increase the dosage. The balance, then, is to take an antidepressant long enough to know if it is working, but to discuss with your doctor in time when a switch makes sense. How best to switch antidepressants depends on your personal situation. Make a practical plan with your doctor. 

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Last Updated on July 23, 2021 by Josette Davignon

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